Welcome to our comprehensive tier list guide for Enigma of Sepia, the mobile gacha RPG that’s generating buzz in the gaming community. This controversial title has captured attention for its unique take on character design, featuring a roster that draws notable inspiration from beloved anime series.
As players dive into this next-gen RPG, understanding character rankings becomes crucial for both competitive play and efficient resource management. Our tier list analysis will help you navigate through the game’s diverse cast, from the straw hat-wearing Nova to the mysterious Satoria and the chainsaw-wielding Denise.

Whether you’re a veteran gacha player or new to the genre, this guide aims to provide clear insights into which characters currently stand out in Enigma of Sepia’s meta. We’ll examine each character’s strengths, weaknesses, and optimal team compositions to help you make informed decisions about your roster development.
Anti-Sépia Alliance Member Profile No.6: Denise
“My devil-hunting antics may seem childish, but I’m ready to risk everything to keep living like this.”
“My dreams aren’t noteworthy like yours, but I’ll work just as hard as you. Please expect it.”#Enigmaofsepia #EOS #Denise pic.twitter.com/EUJNIi6wp1— Enigma of Sépia Official (@Enigma_of_sepia) January 26, 2025
Ready to explore what makes each character tick in this anime-inspired mobile RPG? Let’s dive into our detailed tier rankings.
Rating(s)
- S Tier – These characters are some of the best in the game, and generally excel at fulfilling their role in most scenarios and are highly recommended to build.
- A Tier – Excellent batch of characters, only falling slightly behind the S-tier units, and can play well in most content.
- B Tier – Still worth the investment and can be pretty solid in certain teams or circumstances.
- C Tier – Situational. May not be worth the investment due to limited usage.
- D Tier – Very situational. Not recommended unless under a specific scenario.
S Tier | |
Carmilla, Sandra, Vespera, Chronis, Lumina, Giselle, Eclipsea, Yukari, Satoria, Denise, Nora Zorana, Celestia, Morgana, Erenor, Sepia, Sanguina | |
A Tier | |
Crimson, Ivy Lynn, Mentora, Bipolaris, Scientia, Sylphyra, Royelle, Ginara | |
B Tier | |
Nova, Yurina, Little Rasi, Sylvia, Eldwyn, Naldra, Lena Frost, Aqua Sera, Levia | |
C Tier | |
Mirage, Little Sai, Alfyria | |
D Tier | |
Aurora, Lyra, Elysia, Cheshire, Eliza Thorn, Dr. Lorena, Ayame |